Leucoplasia Verrucosa Proliferativa revisão da literatura com ênfase no diagnóstico, manejo e tratamento
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Publicado:
Jan 7, 2022
Palavras-chave:
Leucoplasia oral;, Câncer Bucal;, Carcinoma espinocelular, Liquen Plano Bucal, Eritrotrasia
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Resumo
As Desordens Potencialmente Malignas Orais descreve um grupo de doenças com risco aumentado de desenvolver o Carcinoma Espinocelular, e a mais comum é a Leucoplasia Oral, que apresenta uma variante agressiva denominada Leucoplasia Verrucosa Proliferativa. Descrita pela primeira vez em 1985 por Hansen et al., a Leucoplasia Verrucosa Proliferativa é considerada uma forma multifocal incomum da doença, com curso clínico agressivo e implacável para malignidade, sem associação com os fatores de risco tradicionais da Leucoplasia Oral. O diagnóstico e manejo dessa variante é um desafio, pois, além da ausência de biomarcadores comprovados que possam predizer seu curso evolutivo, a subjetividade existente na sua avaliação clínica e histopatológica, faz com que a presença ou grau de Displasia Epitelial Oral não consiga determinar se haverá ou não transformação maligna da lesão. Esta revisão irá focar especificamente nos aspectos sobre diagnóstico, transformação maligna, manejo e tratamento da Leucoplasia Verrucosa Proliferativa, variante agressiva da Leucoplasia Oral.
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Como Citar
Barbosa de Azevedo, A. (2022). Leucoplasia Verrucosa Proliferativa. Revista Naval De Odontologia, 48(I). Recuperado de http://portaldeperiodicos.marinha.mil.br/index.php/odontoclinica/article/view/1853
Seção
Revisões de Literatura
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Referências
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3. Dost F, Lê Cao KA, Ford PJ, Farah CS. A retrospective analysis of clinical features of oral malignant and potentially malignant disorders with and without oral epithelial dysplasia. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Dec;116(6):725-33.
4. Ganesh D, Sreenivasan P, Öhman J, Wallström M, Braz-Silva PH, Giglio D, et al. Potentially Malignant Oral Disorders and Cancer Transformation. Anticancer Res. 2018 Jun;38(6):3223-3229.
5. Mello FW, Miguel AFP, Dutra KL, Porporatti AL, Warnakulasuriya S, Guerra ENS, et al. Prevalence of oral potentially malignant disorders: A systematic review and meta-analysis. J Oral Pathol Med. 2018 Aug;47(7):633-640.
6. Nikitakis NG, Pentenero M, Georgaki M, Poh CF, Peterson DE, Edwards P, et al. Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: Current knowledge and future implications. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Jun;125(6):650-669.
7. Woo SB, Grammer RL, Lerman MA. Keratosis of unknown significance and leukoplakia: a preliminary study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Dec;118(6):713–24.
8. Warnakulasuriya S, Kovacevic T, Madden P, Coupland VH, Sperandio M, Odell E, et al. Factors predicting malignant transformation in oral potentially malignant disorders among patients accrued over a 10-year period in South East England. J Oral Pathol Med. 2011 Oct;40(9):677-83.
9. Speight PM, Khurram SA, Kujan O. Oral potentially malignant disorders: risk of progression to malignancy. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Jun;125(6):612-627.
10. Warnakulasuriya S, Ariyawardana A. Malignant transformation of oral leukoplakia: a systematic review of observational studies. J Oral Pathol Med. 2016 Mar;45(3):155-66.
11. Soares AB, Perschbacher K, Perez-Ordonez B. Oral potentially malignant disorders. Mini-Symposium: Head And Neck Pathology. Diagnostic Histopathology. 2018 May;24(5):161-65.
12. Van der Waal I. Historical perspective and nomenclature of potentially malignant or potentially premalignant oral epithelial lesions with emphasis on leukoplakia-some suggestions for modifications. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Jun;125(6):577-581.
13. Hansen LS, Olson JA, Silverman S Jr. Proliferative verrucous leukoplakia. A long-term study of thirty patients. Oral Surg Oral Med Oral Pathol. 1985 Sep;60(3):285-98.
14. Dost F, Lê Cao K, Ford PJ, Ades C, Farah CS. Malignant transformation of oral epithelial dysplasia: a real-world evaluation of histopathologic grading. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Mar;117(3):343-52.
15. van der Waal I. Potentially malignant disorders of the oral and oropharyngeal mucosa; present concepts of management. Oral Oncol. 2010 Jun;46(6):423-5.
16. Celentano A, Glurich I, Borgnakke WS, Farah CS. World Workshop on Oral Medicine VII: Prognostic biomarkers in oral leukoplakia and proliferative verrucous leukoplakia—A systematic review of retrospective studies. Oral Dis. 2020;00:1–33.
17. Kramer IR, Lucas RB, Pindborg JJ, Sobin LH. Definition of leukoplakia and related lesions: an aid to studies on oral precancer. Oral Surg Oral Med Oral Pathol. 1978 Oct;46(4):518-39.
18. El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ (Eds): WHO Classification of Head and Neck Tumours (4th edition). IARC: Lyon 2017. p. 112–5.
19. Villa A, Gohel A. Oral potentially malignant disorders in a large dental population. J Appl Oral Sci. 2014 Nov-Dec;22(6):473-6.
20. Awadallah M, Idle M, Patel K, Kademani D. Management update of potentially premalignant oral epithelial lesions. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Jun;125(6):628-636.
21. Lingen MW, Pinto A, Mendes RA, Franchini R, Czerninski R, Tilakaratne WM, et al. Genetics/epigenetics of oral premalignancy: current status and future research. Oral Dis. 2011 Apr;17 Suppl 1:7-22.
22. Arduino PG, Bagan J, El-Naggar AK, Carrozzo M. Urban legends series: oral leukoplakia. Oral Dis. 2013 Oct;19(7):642-59.
23. Ranganathan K, Kavitha L. Oral epithelial dysplasia: Classifications and clinical relevance in risk assessment of oral potentially malignant disorders. J Oral Maxillofac Pathol. 2019 Jan-Apr;23(1):19-27.
24. Li CC, Almazrooa S, Carvo I, Salcines A, Woo SB. Architectural Alterations in Oral Epithelial Dysplasia are Similar in Unifocal and Proliferative Leukoplakia. Head Neck Pathol. 2020 Sep 16.
25. Woo SB. Oral Epithelial Dysplasia and Premalignancy. Head Neck Pathol. 2019 Sep;13(3):423-439.
26. Waldron CA, Shafer WG. Leukoplakia revisited. A clinicopathologic study 3256 oral leukoplakias. Cancer. 1975 Oct;36(4):1386-92.
27. Müller S. Oral epithelial dysplasia, atypical verrucous lesions and oral potentially malignant disorders: focus on histopathology. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Jun;125(6):591–602.
28. Torrejon-Moya A, Jané-Salas E, López-López J. Clinical manifestations of oral proliferative verrucous leukoplakia: A systematic review. J Oral Pathol Med. 2020 May;49(5):404–408.
29. Tilakaratne WM, Jayasooriya PR, Jayasuriya NS, De Silva RK. Oral epithelial dysplasia: Causes, quantification, prognosis, and management challenges. Periodontol 2000. 2019 Jun;80(1):126‐147.
30. Villa A, Menon RS, Kerr AR, De Abreu Alves F, Guollo A, Ojeda D, et al. Proliferative leukoplakia: Proposed new clinical diagnostic criteria. Oral Dis. 2018 Jul;24(5):749–60.
31. Napier SS, Speight PM. Natural history of potentially malignant oral lesions and conditions: an overview of the literature. J Oral Pathol Med. 2008 Jan;37(1):1-10.
32. Fitzpatrick SG, Honda KS, Sattar A, Hirsch SA. Histologic lichenoid features in oral dysplasia and squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Apr;117(4):511–20.
33. Abadie WM, Partington EJ, Fowler CB, Schmalbach CE. Optimal Management of Proliferative Verrucous Leukoplakia: A Systematic Review of the Literature. Otolaryngol Head Neck Surg. 2015 Oct;153(4):504-11.
34. Farah CS, Fox SA. Dysplastic oral leukoplakia is molecularly distinct from leukoplakia without dysplasia. Oral Dis. 2019 Oct;25(7):1715-1723.
35. Villa A, Hanna GJ, Kacew A, Frustino J, Hammerman PS, Woo SB. Oral keratosis of unknown significance shares genomic overlap with oral dysplasia. Oral Dis. 2019 Oct;25(7):1707-1714.
36. Silverman S Jr, Gorsky M, Lozada F. Oral leukoplakia and malignant transformation. A follow-up study of 257 patients. Cancer. 1984 Feb 1;53(3):563-8.
37. Hsue SS, Wang WC, Chen CH, Lin CC, Chen YK, Lin LM. Malignant transformation in 1458 patients with potentially malignant oral mucosal disorders: a follow-up study based in a Taiwanese hospital. J Oral Pathol Med. 2007 Jan;36(1):25-9.
38. Mehanna HM, Rattay T, Smith J, McConkey CC. Treatment and follow-up of oral dysplasia - a systematic review and meta-analysis. Head Neck. 2009 Dec;31(12):1600-9.
39. Brouns E, Baart J, Karagozoglu K, Aartman I, Bloemena E, van der Waal I. Malignant transformation of oral leukoplakia in a welldefined cohort of 144 patients. Oral Dis. 2014 Apr;20(3):e19–24.
40. Bagan JV, Jiménez-Soriano Y, Diaz-Fernandez JM, Murillo-Cortés J, Sanchis-Bielsa JM, Poveda-Roda R, et al. Malignant transformation of proliferative verrucous leukoplakia to oral squamous cell carcinoma: a series of 55 cases. Oral Oncol. 2011 Aug;47(8):732-5.
2. Villa A, Villa C, Abati S. Oral cancer and oral erythroplakia: an update and implication for clinicians. Aust Dent J. 2011 Sep;56(3):253-6.
3. Dost F, Lê Cao KA, Ford PJ, Farah CS. A retrospective analysis of clinical features of oral malignant and potentially malignant disorders with and without oral epithelial dysplasia. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Dec;116(6):725-33.
4. Ganesh D, Sreenivasan P, Öhman J, Wallström M, Braz-Silva PH, Giglio D, et al. Potentially Malignant Oral Disorders and Cancer Transformation. Anticancer Res. 2018 Jun;38(6):3223-3229.
5. Mello FW, Miguel AFP, Dutra KL, Porporatti AL, Warnakulasuriya S, Guerra ENS, et al. Prevalence of oral potentially malignant disorders: A systematic review and meta-analysis. J Oral Pathol Med. 2018 Aug;47(7):633-640.
6. Nikitakis NG, Pentenero M, Georgaki M, Poh CF, Peterson DE, Edwards P, et al. Molecular markers associated with development and progression of potentially premalignant oral epithelial lesions: Current knowledge and future implications. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Jun;125(6):650-669.
7. Woo SB, Grammer RL, Lerman MA. Keratosis of unknown significance and leukoplakia: a preliminary study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Dec;118(6):713–24.
8. Warnakulasuriya S, Kovacevic T, Madden P, Coupland VH, Sperandio M, Odell E, et al. Factors predicting malignant transformation in oral potentially malignant disorders among patients accrued over a 10-year period in South East England. J Oral Pathol Med. 2011 Oct;40(9):677-83.
9. Speight PM, Khurram SA, Kujan O. Oral potentially malignant disorders: risk of progression to malignancy. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Jun;125(6):612-627.
10. Warnakulasuriya S, Ariyawardana A. Malignant transformation of oral leukoplakia: a systematic review of observational studies. J Oral Pathol Med. 2016 Mar;45(3):155-66.
11. Soares AB, Perschbacher K, Perez-Ordonez B. Oral potentially malignant disorders. Mini-Symposium: Head And Neck Pathology. Diagnostic Histopathology. 2018 May;24(5):161-65.
12. Van der Waal I. Historical perspective and nomenclature of potentially malignant or potentially premalignant oral epithelial lesions with emphasis on leukoplakia-some suggestions for modifications. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Jun;125(6):577-581.
13. Hansen LS, Olson JA, Silverman S Jr. Proliferative verrucous leukoplakia. A long-term study of thirty patients. Oral Surg Oral Med Oral Pathol. 1985 Sep;60(3):285-98.
14. Dost F, Lê Cao K, Ford PJ, Ades C, Farah CS. Malignant transformation of oral epithelial dysplasia: a real-world evaluation of histopathologic grading. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Mar;117(3):343-52.
15. van der Waal I. Potentially malignant disorders of the oral and oropharyngeal mucosa; present concepts of management. Oral Oncol. 2010 Jun;46(6):423-5.
16. Celentano A, Glurich I, Borgnakke WS, Farah CS. World Workshop on Oral Medicine VII: Prognostic biomarkers in oral leukoplakia and proliferative verrucous leukoplakia—A systematic review of retrospective studies. Oral Dis. 2020;00:1–33.
17. Kramer IR, Lucas RB, Pindborg JJ, Sobin LH. Definition of leukoplakia and related lesions: an aid to studies on oral precancer. Oral Surg Oral Med Oral Pathol. 1978 Oct;46(4):518-39.
18. El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ (Eds): WHO Classification of Head and Neck Tumours (4th edition). IARC: Lyon 2017. p. 112–5.
19. Villa A, Gohel A. Oral potentially malignant disorders in a large dental population. J Appl Oral Sci. 2014 Nov-Dec;22(6):473-6.
20. Awadallah M, Idle M, Patel K, Kademani D. Management update of potentially premalignant oral epithelial lesions. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Jun;125(6):628-636.
21. Lingen MW, Pinto A, Mendes RA, Franchini R, Czerninski R, Tilakaratne WM, et al. Genetics/epigenetics of oral premalignancy: current status and future research. Oral Dis. 2011 Apr;17 Suppl 1:7-22.
22. Arduino PG, Bagan J, El-Naggar AK, Carrozzo M. Urban legends series: oral leukoplakia. Oral Dis. 2013 Oct;19(7):642-59.
23. Ranganathan K, Kavitha L. Oral epithelial dysplasia: Classifications and clinical relevance in risk assessment of oral potentially malignant disorders. J Oral Maxillofac Pathol. 2019 Jan-Apr;23(1):19-27.
24. Li CC, Almazrooa S, Carvo I, Salcines A, Woo SB. Architectural Alterations in Oral Epithelial Dysplasia are Similar in Unifocal and Proliferative Leukoplakia. Head Neck Pathol. 2020 Sep 16.
25. Woo SB. Oral Epithelial Dysplasia and Premalignancy. Head Neck Pathol. 2019 Sep;13(3):423-439.
26. Waldron CA, Shafer WG. Leukoplakia revisited. A clinicopathologic study 3256 oral leukoplakias. Cancer. 1975 Oct;36(4):1386-92.
27. Müller S. Oral epithelial dysplasia, atypical verrucous lesions and oral potentially malignant disorders: focus on histopathology. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Jun;125(6):591–602.
28. Torrejon-Moya A, Jané-Salas E, López-López J. Clinical manifestations of oral proliferative verrucous leukoplakia: A systematic review. J Oral Pathol Med. 2020 May;49(5):404–408.
29. Tilakaratne WM, Jayasooriya PR, Jayasuriya NS, De Silva RK. Oral epithelial dysplasia: Causes, quantification, prognosis, and management challenges. Periodontol 2000. 2019 Jun;80(1):126‐147.
30. Villa A, Menon RS, Kerr AR, De Abreu Alves F, Guollo A, Ojeda D, et al. Proliferative leukoplakia: Proposed new clinical diagnostic criteria. Oral Dis. 2018 Jul;24(5):749–60.
31. Napier SS, Speight PM. Natural history of potentially malignant oral lesions and conditions: an overview of the literature. J Oral Pathol Med. 2008 Jan;37(1):1-10.
32. Fitzpatrick SG, Honda KS, Sattar A, Hirsch SA. Histologic lichenoid features in oral dysplasia and squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Apr;117(4):511–20.
33. Abadie WM, Partington EJ, Fowler CB, Schmalbach CE. Optimal Management of Proliferative Verrucous Leukoplakia: A Systematic Review of the Literature. Otolaryngol Head Neck Surg. 2015 Oct;153(4):504-11.
34. Farah CS, Fox SA. Dysplastic oral leukoplakia is molecularly distinct from leukoplakia without dysplasia. Oral Dis. 2019 Oct;25(7):1715-1723.
35. Villa A, Hanna GJ, Kacew A, Frustino J, Hammerman PS, Woo SB. Oral keratosis of unknown significance shares genomic overlap with oral dysplasia. Oral Dis. 2019 Oct;25(7):1707-1714.
36. Silverman S Jr, Gorsky M, Lozada F. Oral leukoplakia and malignant transformation. A follow-up study of 257 patients. Cancer. 1984 Feb 1;53(3):563-8.
37. Hsue SS, Wang WC, Chen CH, Lin CC, Chen YK, Lin LM. Malignant transformation in 1458 patients with potentially malignant oral mucosal disorders: a follow-up study based in a Taiwanese hospital. J Oral Pathol Med. 2007 Jan;36(1):25-9.
38. Mehanna HM, Rattay T, Smith J, McConkey CC. Treatment and follow-up of oral dysplasia - a systematic review and meta-analysis. Head Neck. 2009 Dec;31(12):1600-9.
39. Brouns E, Baart J, Karagozoglu K, Aartman I, Bloemena E, van der Waal I. Malignant transformation of oral leukoplakia in a welldefined cohort of 144 patients. Oral Dis. 2014 Apr;20(3):e19–24.
40. Bagan JV, Jiménez-Soriano Y, Diaz-Fernandez JM, Murillo-Cortés J, Sanchis-Bielsa JM, Poveda-Roda R, et al. Malignant transformation of proliferative verrucous leukoplakia to oral squamous cell carcinoma: a series of 55 cases. Oral Oncol. 2011 Aug;47(8):732-5.